The third season of Prison Break, an American serial drama television series, commenced airing in the United States on September 17, 2007. Prison Break is produced by Adelstein-Parouse Productions, in association with Rat Entertainment, Original Film and 20th Century Fox Television. The season contains 13 episodes, and concluded on February 18, 2008. The season was shorter than the previous two because of the Writer's Guild strike.

Prison Break revolves around two brothers: one who has been sentenced to death for a crime he did not commit and his younger sibling, a genius structural engineer, who devises an elaborate plan to help him escape prison. The two brothers escape prison in the first season, but are hunted down during the second season and ultimately Michael is recaptured and sent to a Panamanian jail, Penitenciaría Federal de Sona, at the end of the second season. The third season revolves around Michael's breakout from Sona with several other inmates.

For the season, three characters are removed, and four new characters are added as series regulars. Filming continued to take place in Dallas, Texas.